Physiological and Biochemical Changes in Diabetic Rats Treated with Combined Extracts of Artemisia herba-alba and Anabasis syriac

Background and Objective: Diabetes is a global health problem that affects various organs such as the liver, heart and kidney. Patients with diabetes mellitus (DM) who are unsatisfied with conventional therapy are more likely to utilize herbal medicine to improve the effectiveness of the conventional medication. Some herbal extracts such as Artemisia herba alba and Anabasis syriaca are more likely to prevent DM?s consequences. Therefore, the present research was designed to examine the impact of a combined extract of Artemisia herba alba and Anabasis syriaca on blood glucose (BG) levels and lipid profile as well as kidney and liver functions in streptozotocin-induced diabetic rats. Materials and Methods:Artemisia herba alba and Anabasis syriaca leaves separately were collected and air-dried for 4 weeks at room temperature (23-27EC). A stock solution was prepared of 100 mg of dry ethanol extracts and dissolved in 10 mL ethanol. The 36 Wistar albino rats were randomly assigned into six groups (N = 6): Control group, Streptozotocin, (STZ-diabetic group), Artemisia herba alba with STZ (extract1 group), Anabasis syriaca with STZ (extract 2 groups), extract 1 and extract 2 (group) and metformin group. The experiment was applied for 28 days. Results: Significant blood glucose levels reduction was observed when administrated with combined extracts (161.03?19.6 mg dLG1 , p<0.05) compared with the STZ group with a mean value of 460.9?121.9 mg dLG1 . Significantly increased the level of HDL (67.06?38.8 mg dLG1 ) compared with the diabetic group (34.33?1.07 mg dLG1 ) when administrated E1 extract in diabetic rats combined extract decreased serum triglycerides level. Various plants extracts have not shown a significant effect on other study parameters cholesterol, LDL, AST and kidney function tests. Conclusion: The present study showed that the combined effect of Artemisia herba alba and Anabasis syriaca extracts has shown a potential antidiabetic and hypolipidemic impact in streptozotocin-induced diabetic rats.