Effect of green coffee and orlistat on obese individuals.

Background and Objective: Obesity is a condition in which excess body fat has accumulated to such an extent that it may hurt health correlated with various diseases and conditions, particularly cardiovascular diseases and type 2 diabetes. The present study represents the evaluation result of green coffee beans compared to anti obese orlistat drug in some physiological vital parameters levels among obese male humans. Materials and Methods: Sixty males of age 30 years or older were recruited for the study and divided into four groups each of 15 persons done among Jordanian people at Al-Mafraq city in Jordan for one month. Group 1 received 120 mg orlistat once daily, Group 2 have taken 350 mg green coffee beans 3 times daily, Group 3 have taken the combination of orlistat and green coffee as the previous daily table and group 4 was a control group that didn?t receive either orlistat or green coffee. Results: The present data showed that green coffee beans exerted a reduction of about 15-21% in fast blood glucose and lipid parameters (cholesterol, triglyceride, and LDH) in addition to a 32% increase in HDL. On the other hand, orlistat showed less effect on these parameters about 8-13%. No noticeable effect of either green coffee or orlistat on blood pressure. Among physiological minerals, Mg increased significantly (30%) due to green coffee uptake compared to a similar effect of orlistat, whereas, other minerals (Zn, Ca, Mg) and vitamin B12 were not affected in the presence of either green coffee or orlistat. The combination of green coffee and orlistat didn?t exert an additive effect on all parameters. Conclusion: Green coffee may be recommended to improve some physiological parameters such as the reduction in cholesterol, triglyceride, LDH and an increase in HDL levels. Moreover, an increase in Mg levels in obese people.