Aromatic Phosphinous Amides: A Promising New Generation of Antibiotics for Multidrug-Resistant Bacterial Infections

here is a focus on using aromatic phosphinous amide as an antibacterial agent against serious multidrugresistant bacterial infections. N?(4?acetylphenyl)?P,P?diphenyl-phosphinous amide and its corresponding thioxo-phosphinous amide and selenoxo-phosphinous amide were synthesized and designated Ph1, Ph2, and Ph3, respectively.They were structurally identified by single crystal X-ray diffraction, multinuclear NMR spectroscopy, and elementalanalysis. Because their antibacterial activities have never been examined, this study aimed to assess their antibacterialactivities against both Gram-positive and Gram-negative bacteria as well as readily available standard bacterial strains.Two bacterial isolates were isolated from urine specimens collected from patients with urinary tract infections anddesignated CS1, and CS2. Phenotypic, biochemical, and molecular approaches were used to identify them. The antibioticsusceptibility/resistance pattern of these isolates was examined by the installed VITEK 2 system. Isolate CS1 is anaerobic Gram-positive, straight rod-shaped, spore forming, occurring singly or in a short chain, whereas isolate CS2 is anaerobic Gram-negative, coccobacilli-shaped, non-spore forming, occurring in pairs or in chains. Both isolates are positivefor catalase and oxidase test. According to an examination of the 16S rRNA gene sequence, the isolates CS1 and CS2 have98% of their similarities with Bacillus and Acinetobacter species, respectively. Isolates CS1 and CS2 are multidrugresistance species. Based on the results of the minimum inhibitory concentration, the standard bacterial strains andisolates CS1 and CS2 showed a wide range in the antibacterial capabilities of the studied phosphinous amides. Incomparison to Ph2 and Ph3, Ph1 has the strongest antibacterial activity against all of the tested bacterial species. Inconclusion, CS1 and CS2 isolates were identified as novel, multi-drug resistant members of the Bacillus andAcinetobacter genera, respectively. The Ph1 molecule represents a promising new generation of antibiotics with notableantibacterial efficacy against multidrug-resistant Gram-positive and Gram-negative microorganisms (PDF) Aromatic Phosphinous Amides: A Promising New Generation of Antibiotics for Multidrug-Resistant Bacterial Infections. Available from: https://www.researchgate.net/publication/383609275_Aromatic_Phosphinous_Amides_A_Promising_New_Generation_of_Antibiotics_for_Multidrug-Resistant_Bacterial_Infections [accessed Jun 30 2025].