Thermal Stability of S-Nitrosothiols: Impact of Alkyl Chain Length and Branching on Thermal Stability and Molecular Docking with Thromboxane (A2) Receptor ?

S-Nitrosothiols (RSNOs) are essential biomolecules involved in various physiological processes, due to their ability to thermally decompose and release nitric oxide (NO). This study investigates the relationship between the variation of the chemical structure of RSNOs and its thermal stability, as well as their binding with the thromboxane A2 (TP) receptor. A series of RSNOs with varying alkyl chain lengths and branching were synthesized and characterized. Thermal stability was evaluated using stepwise isothermal TGA under oxygen and nitrogen atmosphere. Results reveals a direct correlation between chain length and decomposition temperature with longer, straight alkyl chains exhibit higher thermal stability, while branching decreases stability. Isotope labelling studies confirmed the S?N bond cleavage as the initial step in decomposition. Molecular docking studies explored the binding interactions of RSNOs ?