Anti-hyperglycemic Effect and Liver Enzymes Activity of Varthemia iphionoides essential Oil in Diabetic Rats.

The major goal of this study was to evaluate the anti-hyperglycemic effect and the activity of hepatic enzymes after treating the streptozotocin-induced diabetic rats with the essential oil of Varthemia iphionoides . 24 wistar albino rats weighing between 180-200g were randomly grouped into four categories of six rats. Group A, normal control was received distilled water only. Group B, negative diabetic control that consist if six rats induced with streptozotocin. Diabetic group (C) contains Metformin treated rats at concentrations of 100mg/kg. Diabetic group (D) orally treated with of V. iphionoides essential oil at concentrations of 200mg/kg of body weight. The treatment was done daily for two weeks. Transaminase as well anti-diabetic activity assessed by considering level and component of blood d plasma and glucose respectively. This work was conducted at the department of Biology, Yarmouk University, Irbid, Jordan, November, 2017. glucometeric as well as spectrophotometric approaches to quantify level of glucose and hepatic enzymes respectively. Results obtained at this study showed a significant reductions in glucose level in rats treated with V.iphionoides essential oil (P<0.05) compared to that of the diabetic rats. Significant reduction in AST level (P<0.05) was also obtained in group treated with V. iphionoides essential oil and metformin compared with diabetic group .On other hand no significant change in the level of ALP and ALT were noticed between the controls and the treated groups. Conclusion: the result possessed that V. iphionoides essential oil has anti-hyperglycemic activity and therefore safe and shares Metformin same effect on the hepatic enzymes.